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KMID : 0606320030190010067
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Journal of Phamacetical Sciences Sookmyung Women s University
2003 Volume.19 No. 1 p.67 ~ p.71
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Synthesis of 3-(4-Hydroxyphenyl)-1-methyl-4(1H)-quinolinone
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Jeon Ra-Ok
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Abstract
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Isoflavonoids are abundant in natural products and reported with many synthetic variations. However, relatively few examples of quinolone analogs of isoflavones have been described. As part of’our endeavor to pursue biologically active novel isoflavones, we have developed the efficient synthetic route to synthesize azaisoflavones. The key intermediate, 2’-aminochalocone was obtained from substituted aniline and cyclized to afford afaisoflavone.
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